This paper presents a novel approach for improving the efficacy of COVID-19 vaccines against emergent SARS-CoV-2 variants.We have evaluated the immunogenicity of unadjuvanted wild-type (WU S1-RS09cg) and variant-specific (Delta S1-RS09cg and OM S1-RS09cg) S1 subunit protein vaccines delivered either as a monovalent or a trivalent antigen in BALB/c
Oral-facial-digital type I syndrome (OFDI) is a human X-linked dominant-male-lethal developmental disorder caused by mutations in the OFD1 gene.Similar to other inherited disorders associated to ciliary dysfunction OFD type I patients display neurological abnormalities.We characterized the neuronal phenotype that results from Ofd1 inactivation in e
IntroductionFast, accurate, and automatic analysis of histopathological images using digital image processing and deep learning technology is a necessary task.Conventional histopathological image analysis algorithms require the manual design of features, while deep learning methods can achieve fast prediction and accurate analysis, but rely on the